|
KMID : 0606920110190020243
|
|
Biomolecules & Therapeutics
2011 Volume.19 No. 2 p.243 ~ p.247
|
|
|
Effects of Rutaecarpine on the Pharmacokinetics of Caffeine and Its Three Metabolites in Rats
|
|
Seo Young-Min
Noh Keum-Han
Kong Min-Jeong
Lee Dae-Hun
Kang Mi-Jeong
Jahng Yurng Dong
Kang Won-Ku
Jeong Byeong-Seon
Jeong Tae-Cheon
|
|
|
Abstract
|
|
|
|
Rutaecarpine, an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa, has been shown to be anti-infl ammatory. In the present study, a possible interaction between rutaecarpine and caffeine was investigated in male Sprague Dawley rats. Twenty four hr after the oral pretreatment with rutaecarpine at 80 mg/kg for three consecutive days, rats were treated intravenously with 10 mg/kg of caffeine. Compared with control rats, the pharmacokinetic parameters of caffeine in rutaecarpine-pretreated rats were signifi cantly changed, possibly due to the rapid metabolism. The production of three metabolites of caffeine (i.e., paraxanthine, theobromine and theophylline) was also signifi cantly changed in rats pretreated with rutaecarpine. The present results suggest that oral rutaecarpine would change the intravenous pharmacokinetic characteristics of caffeine.
|
|
|
KEYWORD
|
|
|
Rutaecarpine, Caffeine, Pharmacokinetics, Intravenous, Rat, In vivo
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|